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Publications

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There have been over 70 clinical trials that support our method of treatment. A few of these are listed below along with some prominent research studies in case you would like to do some further reading.

Kranzler, H. R., & Kirk, J. (2001). Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta‐analysis. Alcoholism: Clinical and Experimental Research, 25(9), 1335-1341.

Streeton, C., & Whelan, G. (2001). Naltrexone, a relapse prevention maintenance treatment of alcohol dependence: a meta-analysis of randomized controlled trials. Alcohol and Alcoholism, 36(6), 544-552.

Jarosz, J., Miernik, K., Wąchal, M., Walczak, J., & Krumpl, G. (2013). Naltrexone (50 mg) plus psychotherapy in alcohol-dependent patients: a meta-analysis of randomized controlled trials. The American journal of drug and alcohol abuse, 39(3), 144-160.

Donoghue, K., Elzerbi, C., Saunders, R., Whittington, C., Pilling, S., & Drummond, C. (2015). The efficacy of acamprosate and naltrexone in the treatment of alcohol dependence, Europe versus the rest of the world: a meta‐analysis. Addiction, 110(6), 920-930.

Srisurapanont, M., & Jarusuraisin, N. (2005). Naltrexone for the treatment of alcoholism: a meta-analysis of randomized controlled trials. The International Journal of Neuropsychopharmacology, 8(02), 267-280.

Jonas, D. E., Amick, H. R., Feltner, C., Bobashev, G., Thomas, K., Wines, R., ... & Garbutt, J. C. (2014). Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis.Jama, 311(18), 1889-1900.

Rösner, S., Leucht, S., Lehert, P., & Soyka, M. (2008). Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes. Journal of Psychopharmacology, 22(1), 11-23.

Carmen, B., Angeles, M., Ana, M., & María, A. J. (2004). Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review. Addiction, 99(7), 811-828.

Agosti, V. (1995). “The Efficacy of Treatment in Reducing Alcohol Consumption: A Meta-Analysis.” International Journal of Addictions 30:1067-1077.

Altshuler, H.L., Phillips, P.E., & Feinhandler, D.A. (1980). “Alteration of Ethanol Self-Administration by Naltrexone.” Life Sciences 26:679-688.

Bohn, M.J., Kranzler, H.R., Beazoglou, D., & Staehler, B.A. (1994). “Naltrexone and Brief Counseling to Reduce Heavy Drinking.” The American Journal on Addictions 3:91-99.

Garbutt, J.C., West, S.L., Carey, T.S., Lohr, K.N., & Crews, F.T. (1999). “Pharmacological Treatment of Alcohol Dependence: A Review of the Evidence.” Journal of American Medical Association 281:1318-1325.

Heinälä, P., Alho, H., Kiianmaa, K., Lönnqvist, J., Kuoppasalmi, K., Sinclair, J.D., & Kiianmaa, K. (2001). “Targeted Use of Naltrexone Without Prior Detoxification in the Treatment of Alcohol Dependence: A Factorial Double-Blind, Placebo-Controlled Trial.” Journal of Clinical Psychopharmacology 21(3):287-292.

Heinälä, P., Alho, H., Kuoppasalmi, K, Lönnqvist, J, Sinclair, D., & Kiianmaa, K. (1999). “Naltrexone in Alcoholism Treatment: Patient Efficacy and Compliance.” New Research. Program & Abstracts. American Psychiatric Association 1999 Annual Meeting. Washington, DC. May 15-20, 1999.

Kranzler, H.R., Tennen, H., Penta, C., & Bohn, M.J. (1997). “Targeted Naltrexone Treatment of Early Problem Drinkers.” Addictive Behaviors 22:431-436.

Kranzler, H.R., Tennen, H., Penta, C., & Bohn, M.J. (1997). “Targeted Naltrexone Treatment of Early Problem Drinkers.” Addictive Behaviors 22:431-436.

Litten, R.Z., Croop, R.S., Chick, J., McCaul, M.E., Mason, B., & Sass, H.(1996). “International Update: New Findings on Promising Medications.” Alcoholism: Clinical and Experimental Research 20:216A-218A.

Mason, B.J., Ritvo, E.C., Morgan, R.O., Salvato, F.R., Goldberg, G., Welch, B., & Mantero-Atienza, E. (1994). “A Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy and Safety of Oral Nalmefene HCL for Alcohol Dependence.” Alcoholism: Clinical and Experimental Research 18:1162-1167.

Mason, B.J., Salvato, F.R., Williams, L.D., Ritvo, E.C., & Cutler, R.B. (1999). “A Double-Blind, Placebo-Controlled Study of Oral Nalmefene for Alcohol Dependence.” Archives of General Psychiatry 56:719-724.

Maxwell, S. & Shinderman, M.S. (2000). “Use of Naltrexone in the Treatment of Alcohol Use Disorders in Patients with Concomitant Major Mental Illness.” Journal of Addictive Diseases 19(3).

O’Malley, S.S., Jaffe, A.J., Chang, G., Schottenfeld, R.S.,Meyer, R.E., & Rounsaville, B. (1992). “Naltrexone and Coping Skills Therapy for Alcohol Dependence.” Archives of General Psychiatry 49:881-887.

O’Malley, S.S., Jaffe, A.J., Chang, G., Rode, S., Schottenfeld, R.S., Meyer, R.E., & Rounsaville, B. (1996). “Six-month Follow-up of Naltrexone and Psychotherapy for Alcohol Dependence.” Archives of General Psychiatry 53: 217-224.

Renault, P.F. (1980). “Treatment of Heroin-Dependent Persons with Antagonists: Current Status.” In Naltrexone: Research Monograph 28, ed. R.E. Willett & G. Barnett, 11-22. Washington, D.C.: National Institute on Drug Abuse.

Sinclair, J.D. (2001). “Evidence about the Use of Naltrexone and for Different Ways of Using It in the Treatment of Alcoholism.” Alcohol & Alcoholism 36: 2-10.

Sinclair, J.D., Kymäläinen, O., Hernesniemi, M., Shinderman, M.S. & Maxwell, S. (1998). “Treatment of Alcohol Dependence with Naltrexone Utilizing an Extinction Protocol.” 38th Annual Meeting,

National Institute of Mental Health (NIMH) -sponsored New Clinical Drug Evaluation Unit (NCDEU) Program, Boca Raton, Florida, June 10-13, 1998.

Sinclair, J.D., Kymäläinen, O., & Jakobson, B. (1998). “Extinction of the Association between Stimuli and Drinking in the Clinical Treatment of Alcoholism with Naltrexone.” Alcoholism: Clinical and Experimental Research 22: supplement: 144A.

Sinclair, J.D., Vilamo, L., & Jakobson, B. (1994). “Selective Extinction of Alcohol Drinking in Rats with Decreasing Doses of Opioid Antagonists.” Alcoholism: Clinical and Experimental Research 18:489.

Volpicelli, J.R., Alterman, A.I., Hayashida, M.,& O’Brien, C.P. (1992). “Naltrexone in the Treatment of Alcohol Dependence.” Archives of General Psychiatry 49:876-880.

Mann K, Bladström A, Torup L, Gual A, Van den Brink E. Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene. Biol Psychiatry. 2012 Dec 10. doi:pii: S0006-3223(12)00942-0. 10.1016/j.biopsych.2012.10.020.

Heinälä P, Alho H, Kiianmaa K, Lönnqvist J, Kuoppasalmi K, Sinclair JD. Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: a factorial double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2001 Jun;21(3):287-92

For further information regarding these studies, please contact us.